About 200 Egyptian demonstrators took to the streets in the port city of Suez on Sunday demanding for president Abdul Fattah al-Sisi’s resignation.
Dozens were reportedly arrested and police responded with tear gas.
The protests which also took place in Tahrir Square in Cairo on Friday – are in response to corruption allegations against President Sisi’s government.
Protests have been extremely rare under President Sisi, who took power in 2014 after he led the military’s overthrow of Egypt’s first democratically elected president Mohammed Morsi.
But anger has spread since an Egyptian businessman and actor, Mohamed Ali, posted a series of videos online accusing the country’s leader of wasting millions on luxury residences and hotels while millions of Egyptians lived in poverty.
Egypt has pursued a policy of economic austerity in recent years.
Hundreds filled Tahrir Square – a key site of the 2011 Egyptian uprising – late on Friday shouting “Sisi out”, while demonstrations also took place elsewhere around the country.
At least 74 people were arrested, AFP news agency reported. There is no official confirmation.