Daichi Kamada scored a hat-trick in 53 minutes as Eintracht Frankfurt thumped RB Salzburg 4-1 at Commerzbank Arena.
Filip Kostic added a fourth on 56 minutes but Hee-Chan Wang netted an 85th-minute consolation goal to provide the Austrian club with a glimmer of hope.
The Portuguese club raced into a 3-0 lead courtesy of goals from Sebastian Coates, Andraz Sporar and Luciano Vietto, but Edin Visca’s late penalty make Silas wary ahead of the second leg in Turkey.
Sevilla’s Europa League progress hangs in the balance after they salvaged a 1-1 draw away at CFR Cluj.
Ciprian Deac’s spot kick handed the hosts a 59th-minute lead. However, Youssef En Nesyri bagged an important equaliser with eight minutes of normal time remaining.
Meanwhile, Shahktar Donetsk clinched a 2-1 win over Benfica with Alan Patrick breaking the deadlock and Viktor Kovalenko scoring the decisive goal after Pizzi’s penalty.
Shakhtar Donetsk’s Viktor Kovalenko shoots at goal during the 2-1 victory over Benfica
FC Basel plundered three away goals at APOEL Nicosia to all but secure their place in the next round as Raoul Petretta, Valentin Stocker and Arthur Cabral all scored in Cyprus
Malmo took an unlikely lead at Wolfsburg thanks to Isaac Kiese Thelin’s penalty. Josip Brekalo responded just two minutes later and Thelin’s joy turned to despair when he diverted into his own net to give the Bundesliga side a one-goal advantage heading into the second leg.
AZ Alkmaar and LASK played out a 1-1 draw in Holland Teun Koopmeiners’ 86th-minute effort cancelled out Marko Raguz’ first-half effort.