Saudi women are to be allowed to drive from midnight local time (21:00 GMT) after a ban comes to an end.
The change was announced last September and Saudi Arabia issued the first licences to women earlier this month.
It was the only country left in the world where women could not drive and families had to hire private chauffeurs for female relatives.
The move comes amid an intensified crackdown on activists who campaigned for the right to drive.
Human rights group Amnesty says at least eight women’s rights activists are being detained and could face trial in a counter-terrorism court and long prison sentences for their activism.
They include Loujain al-Hathloul, a well-known figure in the campaign for women’s driving rights.
Amnesty has also called for wider reforms in Saudi Arabia, where women remain subject to male guardianship laws.
Human rights groups in the kingdom have campaigned for years to allow women to drive.
Dozens of women were arrested for driving in Riyadh in 1990 and some Saudi women began posting videos of themselves at the wheel in 2008 and between 2011 and 2014.
However, some Saudi men have expressed their dissatisfaction with the change, using an Arabic hashtag on social media that translates as “You won’t drive”.
The lifting of the driving ban is part of Crown Prince Mohammed bin Salman’s programme to modernise some aspects of Saudi society.
He has spearheaded the Vision 2030 programme to diversify the economy away from oil and open up Saudi society.
But there are still limits on what Saudi women can do. Saudi law enforces a strict form of Sunni Islam known as Wahhabism and is known for its gender segregation rules.
Women have to adhere to strict dress codes, must not associate with unrelated men and, if they want to travel, work or access healthcare, must be accompanied by – or receive written permission from – a male guardian.